Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.
Identifieur interne : 000705 ( Main/Exploration ); précédent : 000704; suivant : 000706Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.
Auteurs : Stefanie Reyes [Australie] ; Veronica Cottam ; Deniz Kirik ; Kay L. Double ; Glenda M. HallidaySource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Brain Chemistry, Dopamine Plasma Membrane Transport Proteins (biosynthesis), Dopaminergic Neurons (metabolism), Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Immunohistochemistry, Impulse Control Disorders (genetics), Male, Mesencephalon (metabolism), Receptors, Dopamine (biosynthesis), Substantia Nigra (cytology), Substantia Nigra (metabolism), Ventral Tegmental Area (metabolism).
- MESH :
- chemical , biosynthesis : Dopamine Plasma Membrane Transport Proteins, Receptors, Dopamine.
- cytology : Substantia Nigra.
- genetics : Impulse Control Disorders.
- metabolism : Dopaminergic Neurons, Mesencephalon, Substantia Nigra, Ventral Tegmental Area.
- Aged, Aged, 80 and over, Brain Chemistry, Female, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Immunohistochemistry, Male.
Abstract
Parkinson's disease (PD) patients have increased susceptibility to impulse control disorders. Recent studies have suggested that alterations in dopamine receptors in the midbrain underlie impulsive behaviors and that more impulsive individuals, including patients with PD, exhibit increased occupancy of their midbrain dopamine receptors. The cellular location of dopamine receptor subtypes and transporters within the human midbrain may therefore have important implications for the development of impulse control disorders in PD. The localization of the dopamine receptors (D1-D5) and dopamine transporter proteins in the upper brain stems of elderly adult humans (n = 8) was assessed using single immunoperoxidase and double immunofluorescence (with tyrosine hydroxylase to identify dopamine neurons). The relative amount of protein expressed in dopamine neurons from different regions was assessed by comparing their relative immunofluorescent intensities. The midbrain dopamine regions associated with impulsivity (medial nigra and ventral tegmental area [VTA]) expressed less dopamine transporter on their neurons than other midbrain dopamine regions. Medial nigral dopamine neurons expressed significantly greater amounts of D1 and D2 receptors and vesicular monoamine transporter than VTA dopamine neurons. The heterogeneous pattern of dopamine receptors and transporters in the human midbrain suggests that the effects of dopamine and dopamine agonists are likely to be nonuniform. The expression of excitatory D1 receptors on nigral dopamine neurons in midbrain regions associated with impulsivity, and their variable loss as seen in PD, may be of particular interest for impulse control.
DOI: 10.1002/mds.25493
PubMed: 23674405
Affiliations:
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Double</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23674405</idno><idno type="pmid">23674405</idno><idno type="doi">10.1002/mds.25493</idno><idno type="wicri:Area/PubMed/Corpus">000914</idno><idno type="wicri:Area/PubMed/Curation">000914</idno><idno type="wicri:Area/PubMed/Checkpoint">000726</idno><idno type="wicri:Area/Ncbi/Merge">003B67</idno><idno type="wicri:Area/Ncbi/Curation">003B67</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B67</idno><idno type="wicri:Area/Main/Merge">000705</idno><idno type="wicri:Area/Main/Curation">000705</idno><idno type="wicri:Area/Main/Exploration">000705</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra.</title><author><name sortKey="Reyes, Stefanie" sort="Reyes, Stefanie" uniqKey="Reyes S" first="Stefanie" last="Reyes">Stefanie Reyes</name><affiliation wicri:level="1"><nlm:affiliation>Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Randwick, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Randwick, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Cottam, Veronica" sort="Cottam, Veronica" uniqKey="Cottam V" first="Veronica" last="Cottam">Veronica Cottam</name></author><author><name sortKey="Kirik, Deniz" sort="Kirik, Deniz" uniqKey="Kirik D" first="Deniz" last="Kirik">Deniz Kirik</name></author><author><name sortKey="Double, Kay L" sort="Double, Kay L" uniqKey="Double K" first="Kay L" last="Double">Kay L. Double</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Chemistry</term><term>Dopamine Plasma Membrane Transport Proteins (biosynthesis)</term><term>Dopaminergic Neurons (metabolism)</term><term>Female</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Immunohistochemistry</term><term>Impulse Control Disorders (genetics)</term><term>Male</term><term>Mesencephalon (metabolism)</term><term>Receptors, Dopamine (biosynthesis)</term><term>Substantia Nigra (cytology)</term><term>Substantia Nigra (metabolism)</term><term>Ventral Tegmental Area (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dopamine Plasma Membrane Transport Proteins</term><term>Receptors, Dopamine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Impulse Control Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term><term>Mesencephalon</term><term>Substantia Nigra</term><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Brain Chemistry</term><term>Female</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Immunohistochemistry</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) patients have increased susceptibility to impulse control disorders. Recent studies have suggested that alterations in dopamine receptors in the midbrain underlie impulsive behaviors and that more impulsive individuals, including patients with PD, exhibit increased occupancy of their midbrain dopamine receptors. The cellular location of dopamine receptor subtypes and transporters within the human midbrain may therefore have important implications for the development of impulse control disorders in PD. The localization of the dopamine receptors (D1-D5) and dopamine transporter proteins in the upper brain stems of elderly adult humans (n = 8) was assessed using single immunoperoxidase and double immunofluorescence (with tyrosine hydroxylase to identify dopamine neurons). The relative amount of protein expressed in dopamine neurons from different regions was assessed by comparing their relative immunofluorescent intensities. The midbrain dopamine regions associated with impulsivity (medial nigra and ventral tegmental area [VTA]) expressed less dopamine transporter on their neurons than other midbrain dopamine regions. Medial nigral dopamine neurons expressed significantly greater amounts of D1 and D2 receptors and vesicular monoamine transporter than VTA dopamine neurons. The heterogeneous pattern of dopamine receptors and transporters in the human midbrain suggests that the effects of dopamine and dopamine agonists are likely to be nonuniform. The expression of excitatory D1 receptors on nigral dopamine neurons in midbrain regions associated with impulsivity, and their variable loss as seen in PD, may be of particular interest for impulse control.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Cottam, Veronica" sort="Cottam, Veronica" uniqKey="Cottam V" first="Veronica" last="Cottam">Veronica Cottam</name><name sortKey="Double, Kay L" sort="Double, Kay L" uniqKey="Double K" first="Kay L" last="Double">Kay L. Double</name><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name><name sortKey="Kirik, Deniz" sort="Kirik, Deniz" uniqKey="Kirik D" first="Deniz" last="Kirik">Deniz Kirik</name></noCountry><country name="Australie"><noRegion><name sortKey="Reyes, Stefanie" sort="Reyes, Stefanie" uniqKey="Reyes S" first="Stefanie" last="Reyes">Stefanie Reyes</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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